麦角甾醇 ergosterol 57-87-4上海惠诚生物优势供应

HCC1122

麦角甾醇 ergosterol

57-87-4

Sterols

C28H44O

397

1mg

100mg

solid

95% TLC; GC

麦角固醇；Provitamin D2

(22E)-Ergosta-5,7,22-trien-3beta-ol

24-Methylchlolesta-5,7,22-trien-3b-ol

(22E)-Ergosta-5,7,22-trien-3beta-ol

156-158°C

250℃ (0.01mmHg)

溶于苯和氯仿 ，不溶于水

-20°C

麦角甾醇又称麦角固醇,有维生素D2的作用。上海惠诚生物提供分析用麦角甾醇 ergosterol,并提供化学用麦角甾醇
[α]D20 -110〜-132° (c=1, CHCl3)
Ergosterol 化学用    5g,25g
麦角甾醇是从真菌类酵母与麦角菌中发现的一种植物固醇，在紫外线照射下可被转化为维生素D2。是微生物细胞膜的重要组成部份，对确保细胞膜的完整性，膜结合酶的活性，膜的流动性，细胞活力以及细胞物质运输等起着重要作用。有研究显示麦角固醇可能具有抗肿瘤特性。
1. Y. Zhang et al. “Requirement for Ergosterol in V-ATPase Function Underlies Antifungal Activity of Azole Drugs” PLoS Pathogens, Vol. 6(6) pp. 1-13, 2010
2. M. Bagnat et al. “Lipid rafts function in biosynthetic delivery of proteins to the cell surface in yeast” PNAS, Vol. 97(7) pp. 3254-3259, 2000
3. K. Grey et al. “Amphotericin primarily kills yeast by simply binding ergosterol” PNAS, doi: 10.1073/pnas.1117280109, 2012
4. T. Takaku et al. “Isolation of an Antitumor Compound from Agaricus blazei Murill and Its Mechanism of Action” The Journal of Nutrition, Vol. 131(5) pp. 1409-1413, 2001
5. F. Montañés et al. “Repression of ergosterol biosynthesis is essential for stress resistance and is mediated by the Hog1 MAP kinase and the Mot3 and Rox1 transcription factors” Molecular Microbiology, Vol. 79(4) pp. 1008-1023, 2011