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十八碳四烯酸甲酯(all cis-6,9,12,15)图1

十八碳四烯酸甲酯(all cis-6,9,12,15)

2020-03-09 13:57910询价
价格:未填
品牌:上海惠诚生物
发货:3天内
发送询价
Cat. Number
1277
Chemical Name
十八碳四烯酸甲酯(all cis-6,9,12,15) Methyl stearidonate (all cis-6,9,12,15)
CAS Number
73097-00-4
Mol. Formula
C19H30O2
Mol. Weight
290
Qty 1
25mg
Appearance
liquid
Application Notes
99%,GC, TLC, Identity confirmed by MS
Synonym
十八碳四烯酸甲酯(all cis-6,9,12,15) Methyl stearidonate (all cis-6,9,12,15),C18:4 (all cis-6,9,12,15) Methyl ester; Moroctic acid methyl ester
Solubility
chloroform, hexane, ethyl ether
Storage condition
-20℃
References

Application Notes:

This product is a high purity polyunsaturated fatty acid methyl ester that is ideal for analysis and biological studies. Recently it has been found that conjugated stearidonic acid can be produced by the bacteria bifidobacteria and propionibacteria from stearidonic acid, suggesting an as yet unexplored pathway of stearidonic acid in mammals through intestinal microbes.1 Stearidonic acid, along with similar polyunsaturated fatty acids, demonstrates inhibitory effects on the 5-lipoxygenase pathway,2 tumor necrosis factor,3 and prostoglandin E2,3 thereby suppressing inflammation. Stearidonic acid is the product of the rate-limiting step in the synthesis of eicosapentaenoic acid from alpha-linolenic acid and is thus more readily converted to eicosapentaenoic than is alpha-linolenic acid.4 Eicosapentaenoic acid has been shown to lower the risk of cardiovascular disease and stearidonic acid is therefore also important in reducing this risk.4 Much research is currently being carried out to try to introduce more stearidonic acid into the human diet.

References: 
1. A. Hennessy et al. “The Production of Conjugated alpha-Linolenic, gamma-Linolenic and Stearidonic Acids by Strains of Bifidobacteria and Propionibacteria” Lipids, Vol. 47:3 pp. 313-327, 2012 
2. M. Guichardant et al. “Stearidonic acid, an inhibitor of the 5-lipoxygenase pathway. A comparison with timnodonic and dihomogammalinolenic acid” Lipids, Vol. 28:4 pp. 321-324, 1993 
3. K. Ishihara et al. “Comparison of the effects of dietary alpha-linolenic, stearidonic, and eicosapentaenoic acids on production of inflammatory mediators in mice” Lipids, Vol. 37:5 pp. 481-486, 2002 
4. S. Lemke et al. “Dietary intake of stearidonic acid–enriched soybean oil increases the omega-3 index: randomized, double-blind clinical study of efficacy and safety” Am J Clin Nutr, Vol. 92:4 pp. 766-775, 2010

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