L-threo-Dihydrosphingosine (Safingol) 15639-50-6

H1807-025

L-threo-Dihydrosphingosine (Safingol)

15639-50-6

synthetic

C₁₈H₃₉NO₂

301

25mg

solid

98+% TLC, GC

L-threo-Sphinganine, C18 chain

chloroform, methanol, ethanol, DMSO

-20°C

1. Darges, et al. “Inhibition of leukotriene B4 (LTB4) in human neutrophils by L-threo-dihydrosphingosine” Adv. Exp. Med. Biol, Vol. 400A pp. 387-392, 1997
2. G. Schwartz, et al. “A pilot clinical/pharmacological study of the protein kinase C-specific inhibitor safingol alone and in combination with doxorubicin” Clin. Cancer Res, Vol. 3 pp. 537-543, 1997
3. J. Coward et al. “Safingol (L-threo-sphinganine) induces autophagy in solid tumor cells through inhibition of PKC and the PI3-kinase pathway” Autophagy Vol. 5(2) pp.184-193, 2009
4. M. Dragusin et al. “metabolism of the unnatural anticancer lipid safingol,L-threo-dihydrosphingosine, in cultured cells” Vol. 44 pp. 1772, 2003