岩藻糖单唾液酸神经节苷酯上海惠诚进口

H1526

岩藻糖单唾液酸神经节苷酯 Fucosylated monosialoganglioside GM1;Fucosyl-GM1

71812-11-8

natural

C₇₉H₁₄₁N₃O₃₅•NH₃

1693

500ug

solid

98+% TLC

Fucosyl-GM1

chloroform/methanol/water, 2:1:0.1; forms micellar solution in water

-20°C

1. L. Svennerholm, et al. (eds.), Structure and Function of Gangliosides, New York, Plenum, 1980
2. T. Kolter, R. Proia, K. Sandhoff, Combinatorial Ganglioside Biosynthesis. J. Biol. Chem., July Vol. 277, No. 29, pp. 25859-25862, 2002
3. G. Ragupathi et al. “Immunization of mice with fucosyl-GM1 conjugated with keyhole limpet hemocyanin results in antibodies against human small-cell lung cancer cells” Cancer Immunology, Immunotherapy, Vol. 48 pp. 483-492, 1999
4. M. Yanagisawa, T. Ariga, R. Yu “Fucosyl-GM1 expression and amyloid-β protein accumulation in PC12 cells” Journal of Neuroscience Research, Vol. 84 pp. 1343-1349, 2006
Gangliosides1 are acidic glycosphingolipids that form lipid rafts in the outer leaflet of the cell plasma membrane, especially in neuronal cells in the central nervous system.2 They participate in cellular proliferation, differentiation, adhesion, signal transduction, cell-to-cell interactions, tumorigenesis, and metastasis. Fucosyl-GM1 is a tumor associated ganglioside and is an antigen expressed in small cell lung cancer that is being investigated as a target for vaccines against cancer cells.3 It has been found that Fucosyl-GM1 demonstrates some of the same binding properties as the similar GM1 ganglioside such as affinity for cholera toxin B subunit and interaction with amyloid-beta protein.4