D,L-erythro-PDMP

H1755

D,L-erythro-PDMP

109760-77-2

synthetic

C₂₃H₃₈N₂O₃•HCl

427

100mg

solid

98+% TLC

D,L-erythro-1-Phenyl-2-decanoylamino-3-morpholino-1-propanol•HCl

ethanol, methanol, chloroform, DMSO

-20°C

1. R. Vunnam, N. Radin “Analogs of ceramide that inhibit glucocerebroside synthetase in mouse brain” Chem Phys Lipids, Vol. 26(3) pp. 265-278, 1980
2. N. Radin et al. “Effects of D-threo-PDMP, an inhibitor of glucosylceramide synthetase, on expression of cell surface glycolipid antigen and binding to adhesive proteins by B16 melanoma cells” Journal of Cellular Physiology, Vol. 141(3) pp. 573–583, 1989
3. N. Radin et al. “Effect of an inhibitor of glucosylceramide synthesis on cultured rabbit skin fibroblasts” Journal of Biochemsitry, vol. 108:4 pp. 525-530, 1990
4. N. Radin, et al. “Structural and stereochemical studies of potent inhibitors of glucosylceramide synthase and tumor cell growth” Journal of Lipid Research, Vol. 36 pp. 611-621, 1995