D-threo-PDMP

H1756

D-threo-PDMP

109836-82-0

synthetic

C₂₃H₃₈N₂0₃•HCl

427

10mg

solid

98+% TLC

D-threo-1-Phenyl-2-decanoylamino-3-morpholino-1-propanol•HCl; Activity: glucosylceramide synthase inhibitor

ethanol, methanol

-20°C

1. R. Vunnam, N. Radin, “Analogs of ceramide that inhibit glucocerebroside synthetase in mouse brain” Chem Phys Lipids, Vol. 26(3) pp. 265-278, 1980
2. N. Radin et al. “Effects of D-threo-PDMP, an inhibitor of glucosylceramide synthetase, on expression of cell surface glycolipid antigen and binding to adhesive proteins by B16 melanoma cells” Journal of Cellular Physiology, Vol. 141(3) pp. 573-583, 1989
3. N. Radin, et al., “Structural and stereochemical studies of potent inhibitors of glucosylceramide synthase and tumor cell growth” Journal of Lipid Research, Vol. 36 pp. 611-621, 1995