D-threo-PPMP

H1865

D-threo-PPMP

synthetic

C₂₉H₅₀N₂O₃•HCl

511

10mg

solid

98+% TLC

D-threo-1-Phenyl-2-hexadecanoylamino-3-morpholino-1-propanol•HClActivity: glucosylceramide synthase inhibitor

ethanol, methanol

-20°C

1. B. Maurer et al. “Synergistic Cytotoxicity in Solid Tumor Cell Lines Between N-(4-Hydroxyphenyl)retinamide and Modulators of Ceramide metabolism” Journal of the National Cancer Institute, Vol. 92(23) pp. 1897-1909, 2000
2. A. Puri et al. “Human Erythrocyte Glycolipids Promote HIV-1 Envelope Glycoprotein-Mediated Fusion of CD4+Cells” Biochemical and Biophysical Research Communications, Vol. 242 pp. 219-225, 1998
3. A. Couto et al. “Glycosphingolipids in Plasmodium falciparum: Presence of an active glucosylceramide synthase” European Journal of Biochemistry, Vol. 271 pp. 2204-2214, 2004
4. D. Sillance et al. “Glucosylceramide modulates membrane traffic along the endocytic pathway” Journal of Lipid Research, Vol. 43 pp. 1837-1845, 2002