三烯生育酚γ-Tocotrienol

The four tocopherols (α, β, δ, and γ) and four tocotrienols (α, β, δ, and γ) are forms of vitamin E, which is known for its antioxidant activity.¹ Tocotrienols are found in high concentrations in palm oil and rice bran. Recent studies observe that tocotrienols may be more effective antioxidants than α-tocopherol, the most abundant form of vitamin E.² Spontaneously hypertensive rats fed a diet which includes γ-tocotrienol show significant reduction of systolic blood pressure and an increase of nitric oxide synthase activity in blood vessels.³ γ-Tocotrienol at 20 µM induces apoptosis of malignant sympathoadrenal (+SA) murine mammary epithelial cells.⁴

1 Kamal-Eldin, A., and Appelqvist, L. The chemistry and antioxidant properties of tocopherols and tocotrienols. Lipids 31 671-701 (1996).

2 Osakada, F., Hashino, A., Kume, T., et al. α-Tocotrienol provides the most potent neuroprotection among vitamin E analogs on cultured striatal neurons.Neuropharmacology 47 904-915 (2004).

3 Shah, S., and Sylvester, P.W. Tocotrienol-induced caspase-8 activation is unrelated to death receptor apoptotic signaling in neoplastic mammary epithelial cells. Exp Biol Med 229 745-755 (2004).

4 Newaz, M.A., Yousefipour, Z., Nawal, N., et al. Nitric oxide synthase activity in blood vessels of spontaneously hypertensive rats: Antioxidant protection by γ-tocotrienol. J Physiol Pharmacol 54(3) 319-327 (2003).